Author(s):
1. Gorana Mrđan, Prirodno-matematički fakultet u Novom Sadu, Serbia
2. Tatjana Verbić, Serbia
3. Olivera Marković, Serbia
4. Borko Matijević, Serbia
5. Đenđi Vaštag, Serbia
6. Suzana Apostolov, Univerzitet u Novom Sadu, Prirodno-matematički fakultet, Serbia

Abstract:
Carbohydrazone derivatives represent a very significant class of compounds due to their wide biological activity. Ionization states of functional groups present in the molecule are of vital importance for understanding of the pharmacokinetic and pharmacodynamic properties of the newly synthesized compounds. One of the physicochemical parameters, the ionization constant (pKa), can be used as a molecular descriptor in order to relate structure and activity of a compound, which may indicate further potential application of newly synthesized derivatives. In this work, ionization constants of twenty monocarbohydrazone derivatives were determined using potentiometric method, in order to obtain information about their ionization states under certain conditions.

Key words:
biološka aktivnost, farmakokinetički deskriptori, monokarbohidrazoni, kiselinske konstante, potenciometrija,biološka aktivnost, molekulski deskriptori, monokarbohidrazoni, kiselinske konstante, potenciometrija

Thematic field:
SYMPOSIUM B - Biomaterials and nanomedicine

Date of abstract submission:
03.07.2020.

Conference:
Contemporary Materials 2020 - Savremeni materijali

Applied paper from author