Author(s):
1. Suzana Apostolov, Univerzitet u Novom Sadu, Prirodno-matematički fakultet, Serbia
2. Đenđi Vaštag, Serbia
3. Borko Matijević, Serbia
4. Gorana Mrđan, Prirodno-matematički fakultet u Novom Sadu, Serbia

Abstract:
Thanks to the wide range of applications, azo dyes have a special place among synthetic dyes. Also, the application of azo dyes is conditioned by their impact on humans and the environment. Lipophilicity as one of the most important molecular descriptors indicating the potential biological activity of the compound is determined experimentally for selected derivatives of azo dyes using reversed phase thin-layer chromatography (RP TLC18 F254s) in the mixtures of water and two organic modifiers. By using the relevant software packages for the studied azo dyes are calculated the values of partition coefficient (log P) as standard measure of lipophilicity, important pharamacokinetic predictors and the values of the effective concetration (EC50) as the criteria of acute toxicity for different test organisms. The relationships between chromatographic parameters (RM0 and m) and calculated biological activity parametrs were studied by linear regression analysis.

Key words:
azo dyes, lipophilicity, farmacokinetic predictors , toxicity

Thematic field:
SYMPOSIUM B - Biomaterials and nanomedicine

Date of abstract submission:
19.07.2018.

Conference:
Contemporary Materials 2018 - Savremeni Materijali

Abstract