Author(s):
1. Borko Matijević, Serbia
2. Gorana Mrđan, Prirodno-matematički fakultet u Novom Sadu, Serbia
3. Dragana Mekic, University of Novi Sad, Faculty of Sciences, Department of Chemistry, Biochemistry and Environmental, Serbia
4. Suzana Apostolov, Univerzitet u Novom Sadu, Prirodno-matematički fakultet, Serbia
5. Đenđi Vaštag, Serbia
6. Dušan Mijin, Univerzitet u Beogradu, Tehnološko-metalurški fakultet, Serbia
7. Jelena Lađarević, Serbia

Abstract:
Today’s scientists synthesize a large number of new compounds in order to investigate their potential biological activity and to find their practical applications. Testing the potential activity of new derivatives is always preceded by their complete physicochemical characterization. Of great importance in this area are the studies on the type, intensity and dominance of interactions present between the dissolved compound and the surrounding medium. In this work, using the method of multiple linear correlation of solvatochromic energies, intermolecular interactions of eleven cinnamic acid derivatives in selected solvents were examined. The influence of the solvent was analyzed using two solvatochromic models Kamlet-Taft’s and Catalan’s. In addition to the effect of the solvent, the influence of the structure of the tested compounds on the interactions obtained was also analyzed. This phenomenon was investigated by linear correlation of free energies, using the Hammett equation.

Key words:
biological activity, cinnamic acid derivatives, LFER, LSER, intermolecular interactions

Thematic field:
SYMPOSIUM B - Biomaterials and nanomedicine

Date of abstract submission:
31.07.2025.

Conference:
Contemporary Materials 2025 - Savremeni Materijali

Applied paper from author