Author(s):
1. Zorislava Bajić, Medicinski fakultet Banja Luka , Republic of Srpska, Bosnia and Herzegovina
2. Tanja Šobot, Medicinski fakultet Banja Luka , Republic of Srpska, Bosnia and Herzegovina
3. Đorđe Bajić, JZU Dom zdravlja Banja Luka , Republic of Srpska, Bosnia and Herzegovina
4. Nikola Šobot, klinicki centar republike srpske, Republic of Srpska, Bosnia and Herzegovina

Abstract:
Nanotechnology is a rapidly developing field in the 21st century, and the commercial use of nanomaterials for novel applications is increasing dramatically. Humans may be exposed to nanomaterials through skin contact, inhalation, ingestion and blood circulation. An important mechanism of nanotoxicity is overproduction of reactive oxygen species (ROS) and subsequent development of oxidative stress in tissues. Inorganic materials (metal and metal oxide nanomaterials, quan¬tum dots) may cause oxidative stress through direct generation of ROS from the nanomaterials themselves or from chemical interactions between nanomaterials and biological components. Organic nanomaterials (fullerenes, carbon nanotubes, dendrimers) induce oxidative stress by indirect, cell-derived mechanisms. This includes activa¬tion of the inflammatory immune response and interaction with or disruption of cellular components like membranes and mitochondria. Oxidative stress leads to DNA damage, unregulated cell signaling, change in cell motility, cytotoxicity, apoptosis, and cancer initiation. Superoxide dismutases, peroxidases, and catalases are some of the prominent antioxidant enzymes which play an important role in preventing or limiting the damage caused by ROS.

Key words:
nanomaterials, oxidative stress, antioxidant enzymes

Thematic field:
SYMPOSIUM B - Biomaterials and nanomedicine

Date of abstract submission:
29.07.2017.

Conference:
Contemporary Materials 2017 - Savremeni Materijali

Abstract